Eye check as the new approach in testing for long Covid

By Team IO

A standardized eye examination might reveal in the future whether people are suffering from long Covid syndrome or post-Covid. A team at the Technical University of Munich (TUM) was demonstrated a clear connection between the disease and specific changes to the blood vessels in the eye.

Between ten and 35 percent of those affected continue to experience symptoms such as respiratory problems or fatigue long after contracting COVID-19. So far, no physical features, or so-called biomarkers, are known that can be used to diagnose long Covid reliably. One of the characteristics of Covid-19 is changes to blood vessels. This affects the endothelium, in particular, the inner wall of the blood vessel. As a result of the changes, organs in the body are not supplied with sufficient blood.

Small blood vessels are little studied

To date, the blood vessels studied were mainly large vessels. “However, 90 percent of endothelial cells in the body are in tiny vessels. What happens to these blood vessels in long Covid is barely known,” says the leader of the study, Prof. Christoph Schmaderer, Managing Senior Physician in the Department of Nephrology at Klinikum rechts der Isar, TUM’s university hospital.

“Blood vessels in the eye could offer a clue to the condition of small blood vessels in the whole body,” Schmaderer says. They are easily accessible for examination, he adds. The necessary methods and tools are well-tested and do not require any intervention in the body.

Unveiling the Secrets of Superspreader COVID: Enhanced Understanding through Deliberate Infection of Volunteers

In a study published in Nature, volunteers were intentionally infected with the SARS-CoV-2 virus to better understand viral transmission, disease severity, and the role of COVID-19 tests in reducing viral spread.

Vessels are constricted or dilated less

Schmaderer, co-leader of the study, Dr. Timon Kuchler, and their team describe their results in the scientific journal “Angiogenesis”. Two values, in particular, showed a strong correlation with long Covid illnesses. Firstly, arterioles, i.e. the smallest arteries, were significantly constricted by comparison with the healthy control group. Secondly, venules – but not the arterioles – showed an altered response to light stimulation. The blood vessels dilate if you shine a flickering light into the eye. In the case of patients with long Covid, this response was significantly reduced.

The more inflammatory markers were measured in participants’ blood, the more pronounced the changes were. According to studies, persistent inflammatory responses are suspected of being a further important factor in long Covid.

Pill containing volcanic bacteria prevents next Covid-19 vaccination 

Researchers at the University of Nuremberg (FAU) have found a Covid-19 vaccine that contains bacteria from volcanic areas.

Further studies needed

As the study is comparatively small with 41 sick participants, and was only conducted in a single hospital, no reliable test for long Covid can be derived from the results yet. In the researchers’ opinion, further studies are needed to verify the results. “I am confident that a tool can be developed based on our results to diagnose long Covid confidently,” states Christoph Schmaderer. “We also assume that microcirculation is restricted in the eye and other body parts. This might make the method especially suited for assessing the effectiveness of future therapies for long Covid.”