Erasmus MC and TU Delft open osteoarthritis research lab

By Laio

A new osteoarthritis research facility, the MOBI-lab, has been unveiled. The initiative results from a partnership between Delft University of Technology (TU Delft) and Erasmus University Medical Center (Erasmus MC). This state-of-the-art lab combines dynamic X-ray imaging with biomechanical analysis to detect osteoarthritis in its early stages.

Osteoarthritis is a degenerative joint disease characterized by the breakdown of cartilage, the tissue that cushions the ends of bones within joints. It leads to pain, stiffness, and reduced mobility. Commonly affecting knees, hips, hands, and the spine, the condition worsens over time, often resulting in chronic discomfort. With no current cure, management focuses on alleviating symptoms and maintaining joint function through medication, physical therapy, and lifestyle changes.

With 1.5 million Dutch citizens currently affected by osteoarthritis and projections to reach 2.5 million by 2040, this facility aims to revolutionize diagnosis and treatment. The lab’s unique technology allows researchers to observe joint loading during everyday activities, potentially enabling doctors to initiate appropriate treatments sooner. This breakthrough could significantly reduce patient pain and preserve mobility, offering hope for at least five additional years of quality life for those affected by this debilitating condition.

Top-notch tech

The MOBI-lab integrates dynamic X-ray imaging with biomechanical movement analysis to study how joints are stressed during activities like walking and cycling. This technology provides real-time data, enabling earlier detection of joint damage and abnormal cartilage quality. The goal is to intervene before significant deterioration occurs, offering patients timely and effective treatment options.

Located within Erasmus MC, the MOBI-lab’s strategic positioning allows seamless collaboration between doctors and engineers. This proximity facilitates the rapid implementation of new diagnostic methods. The lab features advanced equipment, including a treadmill that measures foot pressure and ten cameras for detailed motion capture analysis. Such comprehensive tools make it possible to conduct research not available elsewhere, positioning the MOBI-lab at the forefront of osteoarthritis innovation.

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Hundreds of thousands of Dutch suffer from crystal diseases such as gout, pseudogout and osteoarthritis. With the pioneering microscope from Limburg-based Crystalytics, which works with advanced spectroscopic techniques, they can count on a faster and more accurate diagnosis in the future. Thanks to recent funding the company received from LIOF, market entry is getting closer.

A health and technology initiative

The MOBI-lab is part of the larger Convergentie Health & Technology initiative, combining expertise from TU Delft, Erasmus MC, and Erasmus University Rotterdam. Originating from the Medical Delta program, the initiative aims to transform healthcare through technological advancements. By uniting technology, medical knowledge, and social sciences, the collaboration seeks to enhance healthcare delivery and patient outcomes across the region.