Amazec Photonics
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Amazec Photonics, a Dutch photonics-based MedTech start-up, has secured a €1.5 million Seed Round to develop its pioneering minimally invasive diagnosis devices. The round was led by PhotonDelta – a cross-border growth accelerator and ecosystem of photonic chip technology organizations – with several private investors also contributing. The funding will be used to develop devices for clinical trials.

Cardiovascular diseases are the world’s leading cause of death, accounting for 19 million deaths a year. This is partly due to the difficulty in diagnosing conditions, which leads to delays in treatment. Amazec’s solution is a huge step forward in this battle, as it claims much earlier and more accurate diagnosis for minimal costs and complexity.

Amazec Photonics creates easy-to-apply cardiovascular monitoring tools. Existing solutions are complex, invasive, and often inaccurate. The most common technique to measure cardiac output is called thermodilution, which involves injecting a known volume of liquid upstream of the heart and then measuring temperature changes downstream through specialized catheters inserted into the patient. This has several drawbacks, including an inability to be used reliably during routine examination, large variation between measurements, a lack of sensitivity, and high costs. Consequently, it often leads to misdiagnosis – severely impacting the outlook for patients.

Temperature changes

Amazec’s solution uses photonics-based technology to measure temperature changes to a precision of 0.0001˚C (compared to current accuracy of 0.01˚C). The monitoring device is external, so there is no need to insert catheters. Multiple measurements can be made in real time, which improves reliability – this is in contrast to the single measurement used in current methods.

Pim Kat, Amazec Photonics
Pim Kat, Amazec Photonics

Pim Kat, CEO of Amazec Photonics, said: “The number of people suffering from cardiovascular diseases has risen by 93% over the past 25 years and now impacts an estimated 550 million patients worldwide. Many of these people will die or suffer poor health outcomes because the tools we have to diagnose them aren’t good enough. Our solution can make a real difference because not only does it vastly improve the accuracy of testing for cardiovascular disease, but it is also much less invasive and simpler to use. This will substantially reduce costs and open the door to more people being tested regularly.”

Laurens Weers, CFO of PhotonDelta, said: “Amazec has leveraged the power of photonics to create a device that can make a profound impact on the world. Cardiovascular disease is one of the biggest health challenges we face and better diagnosis can be the key to saving millions of lives.”

PhotonDelta’s investment in Amazec Photonics is the latest step in the organization’s goal to create a world-leading photonics industry in the Netherlands. PhotonDelta aims to help build 200 startups, create new applications for photonic chips, and develop infrastructure and talent.

Amazec will begin clinical trials of its device at Catharina Hospital in Eindhoven this year, with an expansion to three other hospitals planned in 2025 and aiming at full scale production and sales across the EU in 2028.